A UK study has shown that a vaccine can protect people against paratyphoid fever. Paratyphoid fever affects over two million people globally each year. Yet no licensed vaccine is currently available. The clinical trial involved six UK sites, including University Hospital Southampton. Volunteers took part locally at the NIHR Southampton Clinical Research Facility (CRF). The new oral vaccine was shown to provide significant protection. There weren’t any safety concerns. ‘Major

A human challenge trial has shown a new vaccine could offer better protection against whooping cough.   This follows a new report that highlights that 2024 whooping cough numbers were at their worst in 30 years.   Whooping cough is a serious and sometimes deadly disease. It affects millions of people worldwide each year.   Vaccines for whooping cough are already part of routine childhood immunisations in the UK. However they don’t provide lifelong protection. They also don’t

A new trial will see if giving steroids to babies with suspected bacterial meningitis improves survival and long-term outcomes. The trial is known as Better Outcomes in Babies with Bacterial meningitis (BOBBi). It will investigate whether this treatment helps more babies survive without long-term difficulties. Patients will take part across the country, including at University Hospital Southampton (UHS). Preventing long-term problems Bacterial meningitis affects about 350 bab

University Hospital Southampton and primary care services are leading a trial to test the nasal flu vaccine in one-year-old children . The FluSNIFF study is inviting families to take part at around 100 GP practices across the UK. Three hospital sites are also taking part. The trial is being led by co-chief investigators Professor Saul Faust and Dr Alasdair Munro from the NIHR Southampton Clinical Research Facility. It is exploring whether the nasal spray flu vaccine, currentl

An expanding pill trialled in Southampton could soon offer a new and affordable weight loss treatment. It follows a successful clinical trial at University Hospital Southampton (UHS). Participants in Southampton took part at the NIHR Clinical Research Facility at UHS. The treatment was developed by Oxford Medical Products (OMP). OMP partnered with the NIHR Southampton Biomedical Research Centre (BRC) for the trial. They also partnered with the NIHR Bristol BRC, and the North

A major new trial has found surgery is the most effective treatment for a common sinus condition, helping to inform future care for...

Aspiring medics joined LifeLab’s summer school to gain hands-on experience and support their university applications. Dozens of young...

Ceri and Harry took part in a clinical trial at University Hospital Southampton. Thousands of premature babies at risk of serious...

Researchers are trialling a new method to help prevent the most common cause of avoidable childhood blindness. More than 1,000 families...

An innovative vaccine that doesn’t need to be refrigerated or frozen has entered its first clinical trial.   The Stablepharma...

A promising blood test does not reduce the time children in hospital have antibiotics, according to a ground-breaking UK study. Overuse...

Patients in the south will have greater access to cutting-edge treatments and clinical trials through a new research centre. Working with...